Identification and validation of novel ERBB2 (HER2, NEU) targets including genes

ABSTRACT: V-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (ERBB2; synonyms HER2, NEU) encodes a transmembrane glycoprotein with tyrosine kinase-specific activity that acts as a major switch in different signal-transduction processes. ERBB2 amplification and overexpression have been found in a number of human cancers, including breast, ovary and kidney carcinoma. Our aim was to detect ERBB2- regulated target genes that contribute to its tumorigenic effect on a genomewide scale. The differential gene expression profile of ERBB2- transfected and wild-type mouse fibroblasts was monitored employing DNA microarrays. Regulated expression of selected genes was verified by RT-PCR and validated by Western blot analysis. Genomewide gene expression profiling identified (i) known targets of ERBB2 signa

ORGANISM(S): Mus musculus

SUBMITTER: Beckers Johannes 

PROVIDER: E-GEOD-16445 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress