Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling by array of human indolent mantle cell lymphoma

ABSTRACT: Mantle cell lymphoma (MCL) is an aggressive neoplasm with poor outcome. However, some patients have an indolent disease (iMCL) and may not require intensive treatment at initial diagnosis. Diagnostic criteria to recognize these patients are not available. We hypothesized that the analysis of the genetic and expression features of the tumors may help to identify patients with an indolent clinical evolution and provide biomarkers that could be used in the clinical setting. Seven patients with an iMCL that did not require chemotherapy for more than 2 years were compared to 15 conventional MCL (cMCL) that needed systemic therapy at diagnosis. MCL were compared with other leukemic lymphoid neoplasms including 17 CLL, 7FL, HCL and 2HCLv.

ORGANISM(S): Homo sapiens

SUBMITTER: Pedro Jares 

PROVIDER: E-GEOD-16455 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Mantle cell lymphoma (MCL) is typically a very aggressive disease with poor outcomes, but some cases display an indolent behavior that might not necessitate treatment at diagnosis. To define molecular criteria that might permit recognition of such cases, we compared the clinicopathologic features, gene expression, and genomic profile of patients who had indolent or conventional disease (iMCL or cMCL). Patients with iMCL displayed nonnodal leukemic disease with predominantly hypermutated IGVH and  ...[more]

Similar Datasets

Transcriptomics Indolent MCL identified by genomic and gene expression profiling
2010-03-04 | GSE16455 | GEO
Transcriptomics Integrated genomic profiling in mantle cell lymphoma
2011-03-31 | E-GEOD-21452 | biostudies-arrayexpress
Transcriptomics Transcription profiling of human indolent and aggressive forms of Chronic Myeloid Leukaemia (CML)
2013-01-30 | E-MIMR-17 | biostudies-arrayexpress
Transcriptomics Gene expression analysis of mantle cell lymphoma (MCL) combined with laser microdissection
2011-06-25 | E-GEOD-30189 | biostudies-arrayexpress
Transcriptomics Integrated genomic profiling in mantle cell lymphoma
2011-04-01 | GSE21452 | GEO
Transcriptomics Transcriptional responses of mantle cell lymphoma (MCL) lines to PKC inhibition
2013-12-01 | E-GEOD-42549 | biostudies-arrayexpress
Transcriptomics Transcriptional responses of mantle cell lymphoma (MCL) lines to IKKB inhibition
2013-12-01 | E-GEOD-52434 | biostudies-arrayexpress
Transcriptomics Transcriptional responses of mantle cell lymphoma (MCL) after NIK knockdown
2013-12-01 | E-GEOD-52435 | biostudies-arrayexpress
Genomics miR-18b overexpression identifies mantle cell lymphoma patients with poor outcome and improves the MIPI-B prognosticator
2015-04-01 | GSE66299 | GEO
Transcriptomics ibrutinib resistance mantle cell lymphoma [Pt_RNA]
2021-04-26 | GSE141335 | GEO