FoxO3 modulates endothelial gene expression and function by direct and indirect mechanisms

ABSTRACT: FoxO transcription factors represent targets of the PI3K/PKB survival pathway controlling important biological processes such as stress responses, cell cycle progression, apoptosis, vascular remodelling and metabolism. Recent studies have demonstrated the existence of alternative mechanisms of FoxO-dependent gene expression beyond classical binding to a FoxO-responsive DNA binding element (FRE). Here we explored the relative contribution of those mechanisms by comparing the transcriptional responses to conditional activation of FoxO3 and a corresponding FRE-binding mutant in primary human endothelial cells. Microarray analysis revealed several functional gene clusters regulated in absence of an intact DNA-binding domain. Notably, both mutants triggered apoptosis albeit with different effic

ORGANISM(S): Homo sapiens

SUBMITTER: Tobias Czymai 

PROVIDER: E-GEOD-16573 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress