Time-series transcriptome profilings of control and Fenretinide-treated human NB4 cells

ABSTRACT: Pharmacological intervention of redox balance in cancer cells often results in oxidative stress-mediated apoptosis, attracting much attention for the development of a new generation of targeted therapy in cancer. However, little is known about mechanisms underlying the conversion from oxidative signaling to downstream activities leading cells to death. We here report a systematic detection of transcriptome changes in response to oxidative signals generated in leukemia cells upon fenretinide treatment, implicating the occurrence of numerous stress-responsive events during the fenretinide induced apoptosis, such as redox response, endoplasmic reticulum stress/unfolded protein response, translational repression and proteasome activation. Moreover, the configuration of these relevant events is

ORGANISM(S): Homo sapiens

SUBMITTER: Kan-kan Wang 

PROVIDER: E-GEOD-16578 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress