Transcriptional effects of LMP3 in MSC

ABSTRACT: Lim Mineralization Protein, splice variant-3 (LMP3) is known to induce osteoblast differentiation as a result of active modulation of selected molecules involved in the osteogenic cascade. LMP3 seems to act as an upstream modulator of osteogenic differentiation, although the complete network of molecular events involved in this process are still largely unknown. In particular, LMP3 seems to act, at least in part, through the upregulation of bone morphogenetic proteins (BMPs) which are known to exert multiple functions, leading to the regulation of diverse cellular processes. Thus, LMP actions inside the cell are likely to involve the activation of main signaling pathways, suggesting a possible wider role of the molecule in cell homeostasis. The aim of this study is to analyze the gene expr

ORGANISM(S): Homo sapiens

SUBMITTER: camilla bernardini 

PROVIDER: E-GEOD-16614 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress