Transcription profiling of human neuroblatoma SH-SY5Y cells: 24h identifies molecular effectors of unconjugated bilirubin

ABSTRACT: The deposition of unconjugated bilirubin (UCB) in selected regions of the brain results in irreversible neuronal damage, or Bilirubin Encephalopathy (BE). Although UCB impairs a large number of cellular functions, the basic mechanisms of neurotoxicity have not yet been fully clarified. While cells can accumulate UCB by passive diffusion, cell protection may involve multiple mechanisms including the extrusion of the pigment as well as pro-survival homeostatic responses that are still unknown. The effects of UCB treatment to SH-SY5Y neuroblastoma cell line were examined by high density oligonucleotide microarrays. 230 genes were induced after 24 hours. A Gene Ontology (GO) analysis showed that a large group of UCB-induced genes were components of the ER stress response. Independent experimen

ORGANISM(S): Homo sapiens

SUBMITTER: Paola Roncaglia 

PROVIDER: E-GEOD-16656 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress