Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse vivo follicular helper CD4 T cells (TFH) versus non follicular helper CD4 T cells (non-TFH)

ABSTRACT: Analysis of in vivo antigen-specific (LCMV-specific, SMARTA TCR transgenic) follicular helper CD4 T cells (CXCR5high),versus non-follicular helper CD4 T cells (CXCR5low), eight days after viral infection. A paper including data analysis of these experiments has been accepted for publication (Robert J. Johnston et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of follicular helper CD4 T cell differentiation). Experiment Overall Design: Analysis of in vivo antigen-specific (LCMV-specific, SMARTA TCR transgenic) follicular helper CD4 T cells (CXCR5high), versus non-follicular helper CD4 T cells (CXCR5low), eight days after viral infection.

ORGANISM(S): Mus musculus

SUBMITTER: Shane Crotty 

PROVIDER: E-GEOD-16697 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation.

Johnston Robert J RJ   Poholek Amanda C AC   DiToro Daniel D   Yusuf Isharat I   Eto Danelle D   Barnett Burton B   Dent Alexander L AL   Craft Joe J   Crotty Shane S  

Science (New York, N.Y.) 20090716 5943

Effective B cell-mediated immunity and antibody responses often require help from CD4+ T cells. It is thought that a distinct CD4+ effector T cell subset, called T follicular helper cells (T(FH)), provides this help; however, the molecular requirements for T(FH) differentiation are unknown. We found that expression of the transcription factor Bcl6 in CD4+ T cells is both necessary and sufficient for in vivo T(FH) differentiation and T cell help to B cells in mice. In contrast, the transcription  ...[more]