Atonal and Senseless perturbations in Drosophila melanogaster eye-antennal imaginal discs.

ABSTRACT: The goal of this study is to identify co-expressed genes downstream of Atonal and Senseless. These gene lists are used as candidate target genes (technically: as foreground sets) in computational predictions of cis-regulatory elements using the cisTargetX method (http://med.kuleuven.be/cme-mg/lng/cisTargetX). Together, the gene expression results and cis-regulatory predictions, yield a gene regulatory network underlying the early events in retinal differentiation. Predicted cis-regulatory interactions have been validated extensively in vivo using enhancer reporter assays and genetic perturbations. Six samples were analyzed for Atonal gain-of-function (GOF) in the eye-antennal imaginal discs of third instar larvae of Drosophila melanogaster, namely three biological repeats for two different

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Iris Leenaerts 

PROVIDER: E-GEOD-16713 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress