Starvation response in Drosophila and its implication for sex specific metabolism and aging

ABSTRACT: Background All animals must be able to adapt to changes in nutrient quality and supply. One striking aspect of this adaptive response is the extension of lifespan when caloric intake is reduced. These animals are also more resistant to various stresses, including starvation. We have characterized the response of adult Drosophila males and females to starvation and sugar conditions using high density microarrays. Results We have organized the regulated genes into specific metabolic and physiologic pathways. Most of the highly regulated genes have a strong sex bias. In addition to expected sex specific changes, such as egg production in females, we found unexpected biases in sensory systems, amino acid and purine metabolism, and signaling pathways. Comparison of starvation to caloric restri

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Matthias Bauer 

PROVIDER: E-GEOD-1672 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress