The unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy

ABSTRACT: In Mycobacterium tuberculosis, the sensor kinases DosT and DosS activate the transcriptional regulator DosR, resulting in the induction of the DosR regulon, important for anaerobic survival and perhaps latent infection. The individual and collective roles of these sensors has been postulated biochemically, but their roles have remained unclear in vivo. This work demonstrates distinct and additive roles for each sensor during anaerobic dormancy. Both sensors are necessary for wild type levels of DosR regulon induction, and concomitantly, full induction of the regulon is required for wild type anaerobic survival. In the anaerobic model, DosT plays an early role, responding to hypoxia. DosT then induces the regulon and with it DosS, which sustains and further induces the regulon. DosT then lo

ORGANISM(S): Mycobacterium tuberculosis H37Rv

SUBMITTER: Ryan Honaker 

PROVIDER: E-GEOD-16811 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress