Genome-wide DNA methylation in normal and IUGR pancreatic islets

ABSTRACT: Intrauterine growth restriction (IUGR) increases susceptibility to age-related diseases including type 2 diabetes (T2DM), and is associated with permanent and progressive changes in gene expression and epigenetic regulation. We studied cytosine methylation throughout the genome in pancreatic islets from a rat model of uteroplacental insufficiency, providing a novel and detailed assessment of the genomic distribution and locus-specific patterns of DNA methylation in normal islets as well as the changes that occur as a consequence of IUGR. Utilizing a high throughput approach to study DNA methylation at almost 1 million unique sites throughout the genome, we found ~1,400 changes in methylation (IUGR compared to control) with an estimated false discovery rate of 4.2%. These epigenetic diff

ORGANISM(S): Rattus norvegicus

SUBMITTER: Melissa Fazzari 

PROVIDER: E-GEOD-16839 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress