Exploring functional relationships between components of the gene expression machinery
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Tien-Hsien Chang
PROVIDER: E-GEOD-1684 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Exploring functional relationships between components of the gene expression machinery.
Burckin Todd T Nagel Roland R Mandel-Gutfreund Yael Y Shiue Lily L Clark Tyson A TA Chong Jean-Leon JL Chang Tien-Hsien TH Squazzo Sharon S Hartzog Grant G Ares Manuel M
Nature structural & molecular biology 20050130 2
Eukaryotic gene expression requires the coordinated activity of many macromolecular machines including transcription factors and RNA polymerase, the spliceosome, mRNA export factors, the nuclear pore, the ribosome and decay machineries. Yeast carrying mutations in genes encoding components of these machineries were examined using microarrays to measure changes in both pre-mRNA and mRNA levels. We used these measurements as a quantitative phenotype to ask how steps in the gene expression pathway ...[more]
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