A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

ABSTRACT: The innate immune system responds to unique molecular signatures that are widely conserved among microbes but that are not normally present in host cells. Compounds that stimulate innate immune pathways may be valuable in the design of novel adjuvants, vaccines, and other immunotherapeutics.The cyclic dinucleotide cyclic-di-guanosine monophosphate (c-di-GMP) is a recently appreciated second messenger that plays critical regulatory roles in many species of bacteria but is not produced by eukaryotic cells. In vivo and in vitro studies have previously suggested that c-di-GMP is a potent immunostimulatory compound recognized by mouse and human cells. Here we provide evidence that c-di-GMP is sensed in the cytosol of mammalian cells via a novel immunosurveillance pathway. The potency of

ORGANISM(S): Mus musculus

SUBMITTER: Russell Vance 

PROVIDER: E-GEOD-16943 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress