Protein translation as major target for gene expression control of O. tsutsugamushi

ABSTRACT: Orientia tsutsugamushi, an obligate intracellular bacterium, is the causative agent of Scrub typhus. The bacterium can replicate both in its arthropod host and in mammals, including humans. The control mechanisms for bacterial gene expression within eukaryotic host cells are largely unknown. Previously, we reported that the O. tsutsugamushi genome has the highest repeat density of any sequenced bacterial genome due to the extraordinary proliferation of mobile genetic elements (MGEs), suggesting a unique genomic evolution in intracellular niches. In this study, the global gene expression of O. tsutsugamushi within eukaryotic cells was examined using a microarray and proteomic approaches. These approaches identified 643 genes, corresponding to approximately 30% of genes encoded in the genome

ORGANISM(S): Orientia tsutsugamushi

SUBMITTER: Chan-Ki Min 

PROVIDER: E-GEOD-16966 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress