Expression Profiling of Early Myogenesis - Affymetrix Dataset

ABSTRACT: Analysis of Early Myogenesis Reveals an Extensive Set of Transcriptional Regulators Whose Knock-down Can Inhibit Differentiation Myogenesis is a tightly controlled process involving the transcriptional activation and repression of thousands of genes. Although many components of the transcriptional network are known for the later phases of myogenesis, relatively little work has described the transcriptional landscape within the first 24 hours, when myoblasts commit to differentiate. Through dense temporal sampling of differentiating C2C12 myoblasts, we identify 266 transcriptional regulators (TRs) whose expression is altered within the first 12 hours of myogenesis. A high-content shRNA screen of 76 TRs involving 427 stable lines identified 48 genes whose knockdown significantly inhibits dif

ORGANISM(S): Mus musculus

SUBMITTER: Saravanan Sundararajan 

PROVIDER: E-GEOD-16992 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress