Microarray analysis of iris gene expression in mice with mutations relevant to glaucoma

ABSTRACT: Several ocular diseases involve the iris, notably including oculocutaneous albinism, pigment dispersion syndrome, and exfoliation syndrome. To screen for candidate genes that may be active in these diseases, genome-wide iris gene expression patterns were comparatively analyzed from mouse models of these conditions. Irides were obtained from healthy C57Bl/6J, B6-Lystbg-J/J which carry a mutation in the Lyst gene, B6(Cg)-TyrC-2J/J which carry a mutation in the tyr gene, and B6.D2-Tryp1bGpnmbR150X/Sj with mutations in both Tryp1 and Gpnmb. Four eyes from two mice were pooled for one sample. Three samples were prepared for each strain.

ORGANISM(S): Mus musculus

SUBMITTER: Colleen Trantow 

PROVIDER: E-GEOD-16994 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress