Dataset Information
SiRNA of human HeLa cells with RENT1 knockdown
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Joshua Mendell
PROVIDER: E-GEOD-1703 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise.
Nature genetics 20040926 10
Premature termination codons induce rapid transcript degradation in eukaryotic cells through nonsense-mediated mRNA decay (NMD). This pathway can modulate phenotypes arising from nonsense or frameshift mutations, but little is known about the physiologic role of NMD in higher eukaryotes. To address this issue, we examined expression profiles in mammalian cells depleted of Rent1 (also called hUpf1), a factor essential for NMD. Upregulated transcripts included those with upstream open reading fram ...[more]
