Comparison of gene expression in 23 Cryptococcus gattii isolates

ABSTRACT: An array analysis of C. gattii (C. bacillosporus), intended to identify loci associated with the hypervirulence of the Vancouver Island Outbreak (VIO). 23 C. gattii isolates, representing both VIO strains and control strains, were grown for 24 hours in mammalian macrophages. RNA was isolated and gene expression for each strain quantified relative to pooled RNA from all 23 samples. Linear regression was used to identify loci showing positive or negative correlation with "intracellular proliferation rate", a proxy measure for virulence. Data from this analysis is included in Ma et al, 2009, PNAS 106(31) 12980-12985. The abstract is included below. In 1999, the population of Vancouver Island, Canada, began to experience an outbreak of a fatal fungal disease caused by a highly virulent l

ORGANISM(S): Cryptococcus bacillisporus

SUBMITTER: Robin May 

PROVIDER: E-GEOD-17052 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress