Transcription profiling of human acute myelogenous leukemia stem cells reveals disregulated gene networks

ABSTRACT: We performed the first genome-wide expression analysis directly comparing the expression profile of highly enriched normal human hematopoietic stem cells (HSC) and leukemic stem cells (LSC) from patients with acute myeloid leukemia (AML). Comparing the expression signature of normal HSC to that of LSC, we identified 3,005 differentially expressed genes. Using 2 independent analyses, we identified multiple pathways that are aberrantly regulated in leukemic stem cells compared with normal HSC. Several pathways, including Wnt signaling, MAP Kinase signaling, and Adherens Junction, are well known for their role in cancer development and stem cell biology. Other pathways have not been previously implicated in the regulation of cancer stem cell functions, including Ribosome and T Cell Receptor S

ORGANISM(S): Homo sapiens

SUBMITTER: Qiang Tian 

PROVIDER: E-GEOD-17054 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress