Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush

ABSTRACT: Retinal ganglion cell (RGC) death is the final consequence of many blinding diseases, where there is considerable variation in the time course and severity of RGC loss. Indeed, this process appears to be influenced by a wide variety of genetic and environmental factors. In this study we explored the genetic basis for differences in ganglion cell death in two inbred strains of mice. We found that RGCs are more susceptible to death following optic nerve crush in C57BL/6J mice (54% survival) than in DBA2/J mice (62% survival). Using the Illumina Mouse-6 microarray, we identified 1,580 genes with significant change in expression following optic nerve crush in these two strains of mice. Our analysis of the changes occurring after optic nerve crush demonstrated that the greatest amount of change

ORGANISM(S): Mus musculus

SUBMITTER: Justin Templeton 

PROVIDER: E-GEOD-17117 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress