Skeletal muscle characteristics of inherited low and high aerobic exercise capacity

ABSTRACT: Epidemiological studies reveal a strong link between low aerobic capacity and metabolic and cardiovascular diseases. Two-way artificial selection of rats based on low and high intrinsic exercise capacity has produced two strains that also differ in risk for metabolic syndrome (Koch LG, Britton SL. Artificial selection for intrinsic aerobic endurance running capacity in rats. Physiol Genomics 5:45-52, 2001). Here we investigated skeletal muscle characteristics and genotype-phenotype relationships behind high and low inherited aerobic exercise capacity and the link between oxygen metabolism and metabolic disease risk factors in rats derived from generation 18. This population (n=24) of high capacity runners (HCR) and low capacity runners (LCR) differed by 615% in maximal treadmill running ca

ORGANISM(S): Rattus norvegicus

SUBMITTER: Heikki Kainulainen 

PROVIDER: E-GEOD-17190 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress