Gene Expression Profiles of CD21low B cells in Common Variable Immunodeficiency

ABSTRACT: The homeostasis of circulating B cell subsets in the peripheral blood of healthy adults is well regulated, but in disease it can be severely disturbed. Thus, a subgroup of patients with common variable immunodeficiency (CVID) presents with an extraordinary expansion of an unusual B cell population characterized by the low expression of CD21. Since these circulating atypical B cells in the blood of CVID patients could not be assigned to any certain B cell differentiation stage in the periphery, they were designated as CD21low B cells. Although, CD21low B cells are polyclonal and unmutated IgM+IgD+ B cells like naive B cells in the peripheral blood, they reveal several distinct phenotypic and functional features. In order to uncover the the global programme of gene expression underlying thes

ORGANISM(S): Homo sapiens

SUBMITTER: Mirzokhid Rakhmanov 

PROVIDER: E-GEOD-17269 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress