Transcriptional profiling of an evolved polymorphism in E. coli

ABSTRACT: Microbial populations founded by a single clone and propagated under resource limitation can become polymorphic. We sought to understand how stable polymorphism arose in an Escherichia coli population that evolved for 765 generations under continuous glucose limitation. Apart from a 29 kb deletion in the dominant clone, no large-scale genomic changes distinguish evolved clones from their common ancestor. However, when co-evolved clones are cultured separately their transcriptional profiles differ markedly from that ancestor, and do so in ways that are consistent with our understanding of how E. coli adapts to glucose limitation. All adaptive clones exhibit reduced activity of the stationary-phase sigma factor σS and increased expression of glucose transport genes, including the glycoporin

ORGANISM(S): Escherichia coli K-12

SUBMITTER: William Holben 

PROVIDER: E-GEOD-17276 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress