Tissue-specific dysregulation of DNA methylation in aging

ABSTRACT: The normal aging process is a complex phenomenon associated with physiological alterations in the function of cells and organs over time. Although an attractive candidate for mediating transcriptional dysregulation, the contribution of epigenetic dysregulation to these progressive changes in cellular function remains unclear. In this study, we employed the genome-wide HELP assay to define patterns of cytosine methylation throughout the rat genome, and the LUMA assay to measure global levels of DNA methylation in the same samples. We studied both liver and visceral adipose tissue, and demonstrated significant differences in DNA methylation with age at >5% of sites analyzed. Furthermore, we showed that epigenetic dysregulation with age is a highly tissue-dependent phenomenon. The most di

ORGANISM(S): Rattus norvegicus

SUBMITTER: Reid Thompson 

PROVIDER: E-GEOD-17332 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress