Transcription profiling of human multiple myeloma cells ( MM1.S) cells with control or beta-catenin knockdown.
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Daniel Ruben Carrasco
PROVIDER: E-GEOD-17385 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression.
Dutta-Simmons Jui J Zhang Yunyu Y Gorgun Gullu G Gatt Moshe M Mani Mala M Hideshima Teru T Takada Kohichi K Carlson Nicole E NE Carrasco Daniel E DE Tai Yu-Tzu YT Raje Noopur N Letai Anthony G AG Anderson Kenneth C KC Carrasco Daniel R DR
Blood 20090803 13
Multiple myeloma (MM) is a cancer of plasma cells with complex molecular characteristics that evolves from monoclonal gammopathy of undetermined significance, a highly prevalent premalignant condition. MM is the second most frequent hematologic cancer in the United States, and it remains incurable, thereby highlighting the need for new therapeutic approaches, particularly those targeting common molecular pathways involved in disease progression and maintenance, shared across different MM subtype ...[more]
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