Transcription profiling of Type I interferon response of human blood monocytes primed with Type II interferon
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ioannis Tassiulas
PROVIDER: E-GEOD-1740 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors.
Tassiulas Ioannis I Hu Xiaoyu X Ho Hao H Kashyap Yogita Y Paik Paul P Hu Yongmei Y Lowell Clifford A CA Ivashkiv Lionel B LB
Nature immunology 20041003 11
A key function of interferons is priming multiple cell types for enhanced activation by cytokines and inflammatory factors, including tumor necrosis factor, bacterial lipopolysaccharide and interferons themselves. Here we show that interferon-alpha (IFN-alpha)-induced activation of the transcriptional activator STAT1 and inflammatory STAT1 target genes was enhanced in IFN-gamma-primed macrophages. Enhanced IFN-alpha signaling and proinflammatory function were dependent on the tyrosine kinase Syk ...[more]
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