Transcriptional signature of Drosophila wing disc regeneration

ABSTRACT: Research on the ability of certain organisms to reconstruct missing structures of their bodies is still in its infancy, despite numerous efforts performed in multiple species. Using expression profile analyses on different timepoints that cover wound healing and regeneration processes (0, 24 and 72 hours post injury), we studied the regenerative behaviour of fragmented wing imaginal discs of D. melanogaster implanted into adult flies. First, through the comparison between cut and intact discs, we identified the effect of implantation on the regeneration process. Filtering this information, we then constructed the specific early regeneration gene signature of wing discs in which multiple transcription factors, immune response genes and members of the JNK, Notch and WNT signaling pathways se

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Montserrat Corominas 

PROVIDER: E-GEOD-17408 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress