De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function

ABSTRACT: Background: Despite significant improvements in short-term kidney transplant survival, comparable increases in 5 and 10-year outcomes have not been achieved. Chronic allograft nephropathy (CAN) is a major cause of late graft loss. Toxic nephropathy and inadequate long-term immunosuppression are possible factors. We performed a randomized prospective trial comparing calcineurin inhibitor (CNI)-free to CNI-based immunosuppression to determine the impact on renal function, structure, and gene expression. Methods: Sixty-one kidney recipients received mycophenolate mofetil (MMF), and prednisone (P). Randomized patients received concentration-controlled sirolimus or cyclosporine. Two years post-transplant 55 patients underwent renal function studies, 48 (87%) underwent transplant biopsies; all

ORGANISM(S): Homo sapiens

SUBMITTER: Sunil Kurian 

PROVIDER: E-GEOD-1743 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress