Murine Embryonic Fibroblasts: Wild-type Stmn1 versus null Stmn1 Cells

ABSTRACT: Background: Stathmin (STMN1) protein functions to regulate assembly of the microtubule cytoskeleton by destabilizing microtubule polymers. Stathmin over-expression has been correlated with cancer stage progression, while stathmin depletion leads to death of some cancer cell lines in culture. In contrast, stathmin-null mice are viable with minor axonopathies and loss of innate fear response. Several stathmin binding partners, in addition to tubulin, have been shown to affect cell motility in culture. To expand our understanding of stathmin function in normal cells, we compared gene expression profiles, measured by microarray and qRT-PCR, of mouse embryo fibroblasts isolated from STMN1+/+ and STMN1-/- mice to determine the transcriptome level changes present in the genetic knock-out of stath

ORGANISM(S): Mus musculus

SUBMITTER: Danielle Ringhoff 

PROVIDER: E-GEOD-17432 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress