EIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

ABSTRACT: Translational regulation plays a critical role in cell growth and proliferation, and its dysregulation results in cancer. Aberrant expression of the mRNA 5’cap-binding protein, eIF4E, has been implicated in cancer development and progression. eIF4E activity is promoted by phosphorylation. Here we show that “knock-in” mice in which eIF4E cannot be phosphorylated are resistant to tumorigenesis in a prostate cancer model. We identify multiple candidate genes involved in the resistance to oncogenic transformation. Importantly, phosphorylation of eIF4E is increased in hormone-refractory prostate cancer, the deadliest stage of the disease. Our results highlight eIF4E phosphorylation as a critical event in tumorigenesis. Comaparison of total RNA and polysomal RNA from mouse embryo fibroblasts der

ORGANISM(S): Mus musculus

SUBMITTER: Ola Larsson 

PROVIDER: E-GEOD-17451 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress