Transcription profiling of mouse embryonic E16.5 temporomandibular joint

ABSTRACT: We conducted a genetic analysis of the developing temporo-mandibular joint (TMJ), a highly specialized synovial joint that permits movement and function of the mammalian jaw. First, we used laser capture microdissection to perform a genome-wide expression analysis of each of its developing components. The expression patterns of genes identified in this screen were examined in the TMJ and compared to other synovial joints including the shoulder joint and the hip joint. Striking differences were noted, indicating that the TMJ forms via a distinct molecular program. Several components of the Hedgehog (Hh) signaling pathway are among the genes identified in the screen, including Gli2, which is expressed specifically in the condyle and in the disk of the developing TMJ. We found that mice defi

ORGANISM(S): Mus musculus

SUBMITTER: Daniel Joseph OConnell 

PROVIDER: E-GEOD-17473 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress