Molecular and functional characterization of alloantigen-specific anergic T-cell suitable for cell therapy

ABSTRACT: IL-10 is an immunomodulant cytokine that plays a central role in controlling inflammation, down-regulating immune responses, and inducing immunological tolerance. IL-10 inhibits the expression of costimulatory molecules and the secretion of inflammatory cytokines by antigen-presenting cells (APC), directly suppresses T-cell proliferation, and promotes T-cell anergy. In this study we demonstrate that IL-10 inhibits primary allogeneic proliferation in total PBMC and induces antigen(Ag)-specific T-cell hyporesponsiveness. IL-10-induced anergy is TGF-beta independent, is associated with a decrease of Ag-specific CTLp frequency, and can be obtained among cells with different degree of HLA disparity. The use of tolerogenic dendritic cells (DC) differentiated in the presence of IL-10 (DC-10) allo

ORGANISM(S): Homo sapiens

SUBMITTER: Stefan Tomiuk 

PROVIDER: E-GEOD-17493 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress