The Rpd3L HDAC complex is essential for the heat stress response in yeast

ABSTRACT: To ensure cell survival and growth during temperature increase, eukaryotic organisms respond with transcriptional activation that results in accumulation of proteins that protect against damage, and facilitate recovery. To define the global cellular adaptation response to heat stress, we performed a systematic genetic screen that yielded 277 yeast genes required for growth at high temperature. Of these, the Rpd3 histone deacetylase complex was enriched. Global gene expression analysis showed that Rpd3 partially regulated gene expression upon heat shock. The Hsf1 and Msn2/4 transcription factors are the main regulators of gene activation in response to heat stress. RPD3-deficient cells had impaired activation of Msn2/4-dependent genes, while activation of genes controlled by Hsf1 was deacet

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Eulalia de Nadal 

PROVIDER: E-GEOD-17514 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress