Coordination of frontline defense mechanisms under severe oxidative stress.

ABSTRACT: Oxidative stress (OS) results from genetic defects or stressful environmental challenges that cause unchecked production of reactive oxygen species (ROS). OS has been implicated in many diseases due to its wide ranging damage to nucleic acids, proteins and lipids. Using Halobacterium salinarum NRC-1, an extremophile that thrives under conditions of excessive OS, we have constructed a systems model for oxidative stress response (OSR) by integrating transcriptional changes induced by treatments with H2O2 and paraquat, functional associations inferred through comparative genomics, and de novo discovered cis-regulatory motifs. Together with phenotypic analysis of mutant strains this has revealed a multi-tiered OS management program to transcriptionally coordinate three peroxidase/catalase e

ORGANISM(S): Halobacterium salinarum

SUBMITTER: Dan Tenenbaum 

PROVIDER: E-GEOD-17515 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress