Transcription profiling of human grafted engineered skin substitutes compared with intact human

ABSTRACT: The goal of the experiment: To characterize the dynamic gene expression profile of engineered human skin in vitro and after grafting, and compare with expression profile of uninjured human skin. Bioengineered skin substitutes can facilitate wound closure in massively burned patients, but deficiencies limit their outcomes compared to native skin autografts. To identify gene programs associated with their in vivo capabilities and limitations, we extended previous gene expression profile analyses to now compare engineered skin following in vivo grafting to both in vitro maturation and to normal human skin. Cultured skin substitutes were grafted to full-thickness wounds in athymic mice; biopsies for microarray analyses were collected at multiple in vitro and in vivo time points. Over 10,000 tr

ORGANISM(S): Homo sapiens

SUBMITTER: Bruce Aronow 

PROVIDER: E-GEOD-17539 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress