Blood pooling experiments on ophthalmalogic phenotypes with Illumina arrays

ABSTRACT: In this study 3 pooling experiments were performed. In each of the 3 cohorts, a 'case' and a 'control' blood pool was compared - the goal being to identify single nucleotide polymorphisms with significantly different estimated pooling allele frequencies between cases and controls. For cohort 1, 100 individuals with blue eye color were placed in one pool (the 'control' pool) and 100 individuals with brown eye color were placed in another pool ( the 'case' pool). In cohort 2, 131 individuals with age-related macular degeneration were placed in one pool, with 216 control individuals in another pool. In cohort 3, 100 individuals with pseudoexfoliation syndrome were placed in a case pool - in this case the cohort 2 control sample was used as 'controls'. The blue/brown pools were hybridized to I

ORGANISM(S): Homo sapiens

SUBMITTER: Stuart Macgregor 

PROVIDER: E-GEOD-17557 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress