Hsa-miR-299-5p overexpression in CD34+ hematopoietic progenitor cells

ABSTRACT: Hemopoiesis entails a series of hierarchically organized events that proceed throughout cell specification and terminates with cell differentiation. Commitment needs the transcription factors effort that, in concert with microRNAs, drives cell fate specification, answering to promiscuous patterns of gene expression by turning on lineage-specific genes and repressing alternate lineage transcripts. Therefore microRNAs and mRNAs cooperate to direct cell fate decisions. We obtained microRNAs profiles from human CD34+ hemopoietic progenitor cells and in-vitro differentiated erythroblasts, megakaryoblasts, monoblasts and myeloblasts precursors and we analyzed them together with the gene expression profiles of the same populations. We found that for most part of microRNAs specifically up-regulate

ORGANISM(S): Homo sapiens

SUBMITTER: Elena Tenedini 

PROVIDER: E-GEOD-17585 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress