Gene expression profiles of thymic neuroendocrine tumors (carcinoids) with ectopic ACTH syndrome

ABSTRACT: Although there has been increased knowledge about the molecular biology of neuroendocrine tumors (NETs), little is known about thymic carcinoids and even less about those with excessive hormone disorders, such as ectopic ACTH syndrome. This study was designed to gain insights into molecular networks underlying the tumorigenesis of thymic carcinoids with ACTH secretion. By an approach integrating cDNA microarray and methods of computational biology, we compare gene expression profile between ACTH-producing thymic carcinoids and normal thymus. Totally there are 63 biological categories increased and 108 decreased in thymic carcinoids. Cell proliferation was stimulated which may explain the relatively uncontrolled cell growth of the tumor. Dysregulation of Notch signaling pathway was likely u

ORGANISM(S): Homo sapiens

SUBMITTER: Guang Ning 

PROVIDER: E-GEOD-17619 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress