Genome wide maps of histone demethylase jmjd3, chromatin state and RNA pol in mouse bone marrow-derived macrophages

ABSTRACT: Inflammatory responses triggered by either microbial or endogenous stimuli rely on a complex transcriptional program that involves the differential expression of hundreds of genes. Jmjd3, a JmjC family histone demethylase (HDM), is quickly induced by the transcription factor NF-kB in response to inflammatory stimuli. Jmjd3 erases a histone mark associated with transcriptional repression and silencing, trimethylated lysine 27 in histone H3 (H3K27me3). Thus, Jmjd3-mediated demethylation of H3K27me3 links inflammation to the control of a histone modification involved in lineage determination, differentiation and tissue homeostasis. However, the specific contribution of Jmjd3 induction to innate immunity and inflammation remains unknown. Here we combined genome-wide mapping and gene knockout s

ORGANISM(S): Mus musculus

SUBMITTER: Vipin Narang 

PROVIDER: E-GEOD-17631 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress