Transcription profiling of immortalized human lung epithelial cells following oncogenic KRAS expression and TBK1 suppression

ABSTRACT: The purpose of the dataset is to analyze expression of genes induced by KRAS and regulated by TBK1; The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard therapies. Although the identification of specific oncogenes has led to the development of clinically effective, molecularly targeted therapies in some cases, KRAS has remained refractory to this approach. An alternative strategy for targeting KRAS is to identify gene products that, when suppressed or inhibited, result in cell death only in the presence of an oncogenic allele. Here we have used systematic RNA interference (RNAi) to detect synthetic lethal partners of oncogenic KRAS and found that the non-canonical IkB kinase, TBK1, was selectively essential in cell

ORGANISM(S): Homo sapiens

SUBMITTER: Pablo Tamayo 

PROVIDER: E-GEOD-17643 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress