Epigenomic Analysis of Aberrantly Methylated Genes in Colorectal Cancer

ABSTRACT: Determination of the profile of genes commonly aberrantly methylated in colorectal cancer (CRC) has substantial potential value for diagnostic and therapeutic application. However, our knowledge of the DNA methylation pattern in CRC is currently limited. Therefore, we analyzed the methylation profile of 27,578 CpG sites spanning more than 14,000 genes in CRC and in adjacent normal mucosa using beadchip array-based technology. We identified 621 CpG sites located in promoter region and CpG islands that were significantly hypermethylated in CRC compared to normal mucosa. Genes on chromosome 18 showed promoter hypermethylation most frequently. According to gene ontology analysis, the most common biologically relevant class of genes affected by methylation was the class associated with the cadh

ORGANISM(S): Homo sapiens

SUBMITTER: Young Kim 

PROVIDER: E-GEOD-17648 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress