Differential Effects of TiO2 Nanotubes on Vascular Cells

ABSTRACT: The response of primary human endothelial (ECs) and vascular smooth muscle cells (VSMCs) to TiO2 nanotube arrays is studied through gene expression analysis. Microarrays revealed that nanotubes enhanced EC proliferation and motility, decreased VSMC proliferation, and decreased expression of molecules involved in inflammation and coagulation in both cell types. Network generated from significantly affected genes suggests that cells may be sensing nanotopographical cues via pathways previously implicated in sensing shear stress. DNA microarrays were used to analyze the response of primary human endothelial (ECs) and vascular smooth muscle cells (VSMCs) to nanotopographical TiO2 surfaces. The experiment incorporated a 1 color design and used Agilent arrays that contained roughly 44,00 60mer

ORGANISM(S): Homo sapiens

SUBMITTER: Andrea Barczak 

PROVIDER: E-GEOD-17676 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress