Genechip analysis of bone marrow osteoprogenitors exposed to microgravity

ABSTRACT: In March 2006, murine Bone Marrow Stromal Cells (BMSC) were flown in the Soyuz 12S to the International Space Station to investigate the effects of microgravity on their osteogenic potential in a three-dimensional environment. BMSC were grown in porous bioceramic Skelite disks (Φ 9 mm x T 1.2 mm). The constructs were exposed to microgravity for ca. 8 days, then fixed for RNA extraction. While the flight experiment was performed in fully automated hardware inside the KUBIK incubator, one group of control samples were incubated inside manually operated hardwares (flight control), and the other control group was incubated under routine laboratory conditions (lab control). The altered gene expression profile was analyzed by Mouse Gene 1.0 ST array (Affymetrix) representing whole-transcript co

ORGANISM(S): Mus musculus

SUBMITTER: Natalija Pujic 

PROVIDER: E-GEOD-17696 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress