Bone marrow gene expression of pediatric acute lymphoblastic leukemia (ALL)

ABSTRACT: Pediatric acute lymphoblastic leukemia (ALL) contains cytogenetically distinct subtypes that respond differently to cytotoxic drugs. Subtype classification can be also achieved through gene expression profiling. However, how to apply such classifiers to a single patient and correctly diagnose the disease subtype in an independent patient group has not been addressed. Furthermore, the underlying regulatory mechanisms responsible for the subtype-specific gene expression patterns are still largely unknown. Here, by combining three published microarray datasets (PMIDs: 12086872, 12730115, 17002788) on 535 Caucasian samples and generating a new dataset on 100 Chinese children ALL samples, we were able to 1) identify a 62-gene classifier with 97.6% accuracy from the Caucasian samples and validat

ORGANISM(S): Homo sapiens

SUBMITTER: Nan Qiao 

PROVIDER: E-GEOD-17703 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress