The Involvement of mir-146 in Microglial Cells (EOC 13.31) During Prion Disease

ABSTRACT: MicroRNAs (miRNAs) are evolutionary conserved, non-coding, gene regulatory RNA molecules found in both plants and animals and amongst almost every cell and tissue type. They are about 22 nucleotides long and are involved in silencing of mRNA through sequence specific binding to the 3’ untranslated region (UTR) of the mRNA subsequently causing translational repression and/or will promote the degradation of protein-coding mRNA. Specifically, the miRNA family, mir-146 a/b, has been previously found to be involved in the regulation of the innate immune response by functioning as a negative regulator to help fine-tune the immune response. Microglial cells are the macrophage of the brain participating as major players of the innate immune response. During prion disease, no immune response is m

ORGANISM(S): Mus musculus

SUBMITTER: Rhiannon Huzarewich 

PROVIDER: E-GEOD-17759 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress