Expression data from B6C3F1 mice treated with 2-butoxyethanol and reduced oxygen
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Petra Koza-Taylor
PROVIDER: E-GEOD-17880 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The role of hypoxia in 2-butoxyethanol-induced hemangiosarcoma.
Laifenfeld Daphna D Gilchrist Annalyn A Drubin David D Jorge Milena M Eddy Sean F SF Frushour Brian P BP Ladd Bill B Obert Leslie A LA Gosink Mark M MM Cook Jon C JC Criswell Kay K Somps Christopher J CJ Koza-Taylor Petra P Elliston Keith O KO Lawton Michael P MP
Toxicological sciences : an official journal of the Society of Toxicology 20091007 1
To understand the molecular mechanisms underlying compound-induced hemangiosarcomas in mice, and therefore, their human relevance, a systems biology approach was undertaken using transcriptomics and Causal Network Modeling from mice treated with 2-butoxyethanol (2-BE). 2-BE is a hemolytic agent that induces hemangiosarcomas in mice. We hypothesized that the hemolysis induced by 2-BE would result in local tissue hypoxia, a well-documented trigger for endothelial cell proliferation leading to hema ...[more]
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