Transcriptional profile in low to high-level macrolide resistant C. jejuni strain selected from NCTC 11168

ABSTRACT: Campylobacter, a major foodborne pathogen, is increasingly resistant to macrolide antibibotics. Previous findings suggeted that development of macrolide resistance in campylobacter requires a multi-step process, but the molecular mechanisms involved in the process are not known. In our study, multiple series of macrolide-resistant C. jejuni mutants were selected in vitro by stepwise exposure of C. jejuni NCTC11168 to increasing concentrations of erythromycin and tylosin. A set of the selected resistance were subjected to microarray and the the global transcriptional profile was analyzed. In this sery, DNA microarray was used to compare the gene expression profiles of macrolide resistant strains (68E1, 68E8 and 68E64) with its parent wild-type strain NCTC11168. The assay identified a small

ORGANISM(S): Campylobacter jejuni

SUBMITTER: Haihong Hao 

PROVIDER: E-GEOD-17881 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress