Transcription profiling of human CD90+ stromal fibromuscular cells from tumor specimens reveals down-regulation in prostate tumor-associated stromal cells involves organ-specific genes

ABSTRACT: The prostate stroma is a key mediator of epithelial differentiation and development, and potentially plays a role in the initiation and progression of prostate cancer. Isolation and characterization of viable populations of the constituent cell types of prostate tumors could provide valuable insight into the biology of cancer. The CD90+ stromal fibromuscular cells from tumor specimens were isolated by cell-sorting and analyzed by DNA microarray. Dataset analysis was used to compare gene expression between normal and tumor-associated reactive stromal cells. Reactive stroma is characterized by smooth muscle differentiation, prostate down-regulation of SPOCK3, MSMB, CXCL13, and PAGE4, bladder down-regulation of TRPA1, HSD17B2, IL24, and SALL1, and an up-regulation of CXC-chemokines. This stud

ORGANISM(S): Homo sapiens

SUBMITTER: Ricardo Vêncio 

PROVIDER: E-GEOD-17906 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress