Dataset Information
Transcription profiling of mouse D10.G4.1 T-cells treated with neuromedin U for different length of time to study the effect of neuromedin on gene expression in T cells.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Sujoy GHOSH
PROVIDER: E-GEOD-1791 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Neuromedin U elicits cytokine release in murine Th2-type T cell clone D10.G4.1.
Journal of immunology (Baltimore, Md. : 1950) 20041201 12
Neuromedin U (NmU), originally isolated from porcine spinal cord and later from other species, is a novel peptide that potently contracts smooth muscle. NmU interacts with two G protein-coupled receptors designated as NmU-1R and NmU-2R. This study demonstrates a potential proinflammatory role for NmU. In a mouse Th2 cell line (D10.G4.1), a single class of high affinity saturable binding sites for (125)I-labeled NmU (K(D) 364 pM and B(max) 1114 fmol/mg protein) was identified, and mRNA encoding N ...[more]
