Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Mouse cardiac tissue: Vehicle treated control vs. 25mg/kg DMNQ

ABSTRACT: Transcriptional profiling of mouse cardiac tissue treated with 25mg/kg DMNQ in 10 ml/kg arachis oil over an acute time course (5 minutes-120 hours) compared to time matached control animals treated with 10ml/kg arachis oil Two colour microarrays with time matched controls against 25mg/kg DMNQ cardiac tissue. Time points studied were 5, 10, 15, 20, 30, 45 minutes and 1, 1.5, 2, 5, 12, 24, 120 hours following dosing, biological replicates n=>2 independent animals at each time point, technical replicate n>1 with reverse labelling at each time point. One array printed onto two slides (A and B), one replicate per array.

ORGANISM(S): Mus musculus

SUBMITTER: Amy Pointon 

PROVIDER: E-GEOD-17915 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation.

Pointon Amy V AV   Walker Tracy M TM   Phillips Kate M KM   Luo Jinli J   Riley Joan J   Zhang Shu-Dong SD   Parry Joel D JD   Lyon Jonathan J JJ   Marczylo Emma L EL   Gant Timothy W TW  

PloS one 20100915 9

<h4>Background</h4>Doxorubicin is one of the most effective anti-cancer drugs but its use is limited by cumulative cardiotoxicity that restricts lifetime dose. Redox damage is one of the most accepted mechanisms of toxicity, but not fully substantiated. Moreover doxorubicin is not an efficient redox cycling compound due to its low redox potential. Here we used genomic and chemical systems approaches in vivo to investigate the mechanisms of doxorubicin cardiotoxicity, and specifically test the hy  ...[more]

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